I think Wheeler has shown excellent promise at centre and should stay there when fit, at the expense of Meli who offers good threat near the line but not the creativity and guile of Wheeler. I would rather play my Nan on the wing than put Meli back there too so I don't personally see that as an option. Makinson should be given a shot on the Wing to use his astonishing pace.
I disagree with the part of him not being a natural centre. Yes he has come through the ranks as a stand off, but he has looked very comfortable both offensively and defensively at centre.